Pharmacometric Tools for Modeling & Simulation
Developed by Justin Wilkins, Bill Denney and Rik Schoemaker, with contributions from a host of others.
Pharmacometric tools for common data analytical tasks; closed-form solutions for calculating concentrations at given times after dosing based on compartmental PK models (1-compartment, 2-compartment and 3-compartment, covering infusions, zero- and first-order absorption, and lag times, after single doses and at steady state, per Bertrand & Mentre (2008) http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf); parametric simulation from NONMEM-generated parameter estimates and other output; and parsing, tabulating and plotting results generated by Perl-speaks-NONMEM (PsN).
To install:
devtools::install_github("kestrel99/pmxTools")or download directly from CRAN.