Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.
| Version: | 2.2-22 |
| Priority: | optional |
| Depends: | survival (≥ 2.36.14), methods, bdsmatrix (≥ 1.3), R (≥ 2.10) |
| Imports: | nlme, Matrix (≥ 1.0) |
| LinkingTo: | bdsmatrix |
| Suggests: | mvtnorm, kinship2 |
| Published: | 2024-08-23 |
| DOI: | 10.32614/CRAN.package.coxme |
| Author: | Terry M. Therneau [aut, cre] |
| Maintainer: | Terry M. Therneau <therneau.terry at mayo.edu> |
| License: | LGPL-2 |
| Copyright: | see file COPYRIGHTS |
| NeedsCompilation: | yes |
| Materials: | NEWS |
| In views: | Agriculture, MixedModels, Survival |
| CRAN checks: | coxme results |
| Reference manual: | coxme.pdf |
| Vignettes: |
Mixed Effects Cox Models (source, R code) Coxme and the Laplace Approximation (source, R code) The lmekin function (source, R code) Special Variance Structures (source, R code) |
| Package source: | coxme_2.2-22.tar.gz |
| Windows binaries: | r-devel: coxme_2.2-22.zip, r-release: coxme_2.2-22.zip, r-oldrel: coxme_2.2-22.zip |
| macOS binaries: | r-release (arm64): coxme_2.2-22.tgz, r-oldrel (arm64): coxme_2.2-22.tgz, r-release (x86_64): coxme_2.2-22.tgz, r-oldrel (x86_64): coxme_2.2-22.tgz |
| Old sources: | coxme archive |
| Reverse depends: | mlma |
| Reverse imports: | bigQF, EQUALSTATS, famSKATRC, highMLR, jstable, MAGNAMWAR, mlmm.gwas, multisite.accuracy, MXM, PenCoxFrail, spicyR |
| Reverse suggests: | AICcmodavg, car, finalfit, gap, injurytools, insight, multcomp, parameters, tram, tramME |
| Reverse enhances: | emmeans, MuMIn |
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