(:source 
   :version  3 
   :ip-name "wais.gdb.org"
   :tcp-port 210
   :database-name "gdb-polym"
   :cost 0.00 
   :cost-unit :free 
   :subjects "science genetics medicine chromosomes biology genome "
   :maintainer "help@gdb.org"
   :description "Server created with WAIS release 8 b6 on May  5 10:38:20 1993 by wais@wais.gdb.org

The Genome Database (GDB) is also accessible as a relational database.
For more information, send mail to help@gdb.org or call (410) 955-9705.

A Wais gateway to GDB is accessible through the World Wide Web by opening
the URL "http://gdbwww.gdb.org/".
 
GDB is supported by the U.S. Department of Energy and the U.S. National 
Institutes of Health, and is hosted at the Johns Hopkins University 
School of Medicine in Baltimore, Maryland.

GDB is updated weekly, generally on Saturday morning (Eastern US time). 
If you attempt to search the database during an update, you will receive 
a message stating that GDB is unavailable.  Please retry your search later.

The following sources contain information on specific GDB areas:

gdb-cell-line.src 
-----------------

    Clonal mammalian cell lines which are useful for genomic mapping
    research. 
 
    Cell line descriptions include the name and type of the cell line,
    the chromosomal breakpoints it contains and information on how to
    obtain the cell line (accession numbers for the ATCC and Coriell
    repositories, and contact information).


gdb-citation.src 
----------------

    Bibliographic citations (often with abstracts) for all GDB data.
    Citations in GDB include journal articles, books, book chapters,
    meeting abstracts and personal communications. The citation record
    also includes a list of linked GDB objects.

gdb-contact.src 
---------------

    Contact information for researchers involved in genome mapping,
    as well as GDB editors and staff.  The contact record includes name, 
    address, phone and fax numbers and email address. Where the contact
    has submitted clones, cell lines or libraries to GDB, these are
    also shown in the record.

gdb-library.src
---------------

    Collections of DNA clones, often from specific regions of the
    genome, useful for mapping research.
 
    The library description includes the library name, type of cloned
    DNA, type of vector used to construct the library, contact 
    information (for researchers and national repositories) and a
    list of clones isolated from the library.

gdb-locus.src 
-------------

    Defined regions of the genome, ranging in size from a single point 
    to an extended region.

    Locus types in GDB include genes, DNA segments, fragile sites and
    breakpoints. Locus descriptions include cytogenetic location,
    official name and symbol, mapping method(s) used and pointers to 
    related GenBank sequence database entries and OMIM documents.

gdb-map.src 
-----------

    Genetic or physical maps representing an ordered set of elements
    (loci or probes) on a chromosome.
 
    Each map is a string of locus or probe symbols separated by
    delimiters which indicate the relationship between neighboring
    elements. 
 
    Included in the database are maps produced from primary experimental
    observations, and maps derived from a consensus of several primary 
    maps. Map descriptions include the mapping method used, a summary
    map location, information about the loci or probes in the map and
    the distances between map objects, where available.

gdb-mutation.src 
----------------

    Less common sequence variations in loci, often responsible for 
    clinical phenotypes.
 
    Mutation descriptions include the type of mutation, location 
    within the gene and comparison of wildtype and mutant DNA and
    protein sequences.

gdb-polym.src 
-------------

    Common variations in the DNA sequence of loci, often useful in
    genetic mapping experiments.
 
    Polymorphism descriptions include the type of variation, the
    methods used to detect the polymorphism, and the nature and
    frequency of the alleles observed in the populations studied.

gdb-probe.src 
-------------

    Reagents for detecting genes, DNA segments and their variation.

    Probe types include cloned, PCR (Polymerase Chain Reaction) and 
    ASO (Allele Specific Oligonucleotide) probes. Probe descriptions
    include information about the loci detected by the probe, contacts
    for obtaining the probe, the probe DNA type, vector information
    (for cloned probes) and primer sequences (for PCR and ASO probes).


"
)
